The Latest Advances in Xeroderma Pigmentosum Treatment
Xeroderma Pigmentosum (XP) is a rare genetic condition that makes individuals extremely sensitive to sunlight. The condition arises when the body lacks the ability to repair damaged DNA caused by UV light exposure. This can result in severe sunburn, premature ageing and an increased risk of skin cancer. Currently, there is no known cure for the disease but several advances in its treatment have been made over the years. Here are some of the latest treatments for XP that may be of interest.
Gene Therapy
Gene therapy is one of the latest and most promising treatments for XP. The treatment involves the use of viruses to deliver a healthy copy of the defective gene to the affected cells. This allows the cells to code for the protein required to repair damaged DNA. Gene therapy has shown potential in treating several diseases, including XP. In a recent study, patients with XP underwent gene therapy and showed significant improvement in the number of DNA lesions on their skin cells.
Topical Creams
Topical creams are also commonly used to treat XP patients. These creams contain a substance called photolyase, which is a naturally occurring enzyme that repairs DNA lesions. Photolyase-based creams have been found to reduce the number of skin lesions and improve skin health in XP patients. Some topical creams also contain DNA repair enzymes that help repair skin cells damaged by UV rays.
Immunosuppressive Drugs
Immunosuppressive drugs are a type of medication used to dampen the body’s immune response. In XP patients, immunosuppressive drugs are used to reduce inflammation caused by UV damage. This can help prevent skin cancer and other complications associated with XP. Immunosuppressive drugs can also improve the skin’s tolerance to UV radiation, allowing XP patients to spend more time outdoors.
Sun Protective Clothing
Sun protective clothing is essential for XP patients as it provides a physical barrier between the skin and harmful UV rays. Sun protective clothing can be made from fabrics that provide high levels of UV protection or treated with a UV-blocking solution. These types of clothing have been found to significantly reduce the number of skin lesions in XP patients and protect against the harmful effects of the sun.
Conclusion
In conclusion, Xeroderma Pigmentosum is a rare genetic disorder that results in severe sensitivity to sunlight. However, significant strides have been made in its treatment to improve the quality of life of those affected. Gene therapy, topical creams, immunosuppressive drugs, and sun protective clothing are some of the latest treatments for XP. Further research is still needed to identify the best treatment options for patients with this rare genetic condition.
